187TiP Phase II, multicenter study of autologous tumor infiltrating lymphocytes (TIL, LN 144/LN-145/LN-145-S1) in patients with solid tumours
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منابع مشابه
A phase I clinical trial utilizing autologous tumor-infiltrating lymphocytes in patients with primary hepatocellular carcinoma.
This report describes an ongoing Phase I clinical trial testing the safety of adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) in patients with primary hepatocellular carcinoma (HCC). Fifteen HCC patients were treated with their activated and expanded TILs following tumor resection. From a total of 17 patients with HCC, TIL were successfully expanded from 15 pat...
متن کاملExpansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors
BACKGROUND We evaluated whether tumor infiltrating lymphocytes (TIL) could be expanded from surgically resected tumors from pancreatic cancer patients. METHODS Tumors were resected from pancreatic cancer patients. Tumors were minced into fragments and cultured in media containing high dose interleukin-2 (IL-2) for up to 6 weeks. T cell phenotype, activation markers, and reactivity were measur...
متن کاملSolid-phase anti-CD3 antibody activation of murine tumor-infiltrating lymphocytes.
Seventeen consecutive s.c. murine tumors, derived from a sarcoma and a colon adenocarcinoma, were cultured in the presence of recombinant interleukin 2 (rIL-2) for growth of tumor-infiltrating lymphocytes (TIL). Identical cultures were activated by solid-phase monoclonal antibody directed against the murine CD3 epsilon-chain, in conjunction with rIL-2. Forty-eight h later, cells were replaced i...
متن کاملTumor Infiltrating Lymphocytes
9 Abstract 10 11 Tumor infiltrating lymphocytes (TILs) have been recognized in various 12 cancers and may reflect a host immune response to malignant cells. TILs 13 are a heterogeneous population of various types of mononuclear cells, 14 including CD8 or CD4 + T cells and their subsets, B cells, myeloid 15 derived suppressor cells (MDSC), macrophages, and other cells. Immuno16 suppressive facto...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2021
ISSN: 1556-0864
DOI: 10.1016/s1556-0864(21)02029-3